This case concerns the on-screen display option in ASUS GPU Tweak II; it does not justify disabling unrelated Windows display features.
- Browsers and third-party applications froze immediately while core Windows apps still opened.
- Open ASUS GPU Tweak II.
- Locate and disable OSD mode.
- Restart affected applications or Windows.
- Repeat the keystroke/workload that previously caused freezing.
Reported outcome: The original poster marked the issue solved after discovering OSD mode had been enabled and disabling that mode.
Record the previous OSD setting. Re-enable it to undo the comparison if the same applications still freeze.